Surgery alone, more or less demolitive, is the treatment of choice of
vulvar cancers. Cure rates are high for early cancers only, while loca
lly advanced tumors with or without inguinal adenopathies and recurren
ces have a bad prognosis. the excellent results of concurrent chemo-ra
diotherapy of anal cancers suggested to adopt the same approach for lo
cally advanced vulvar cancers. The shrinkage of the tumor allowed surg
ery, often less demolitive than usual, and the pathological examinatio
n demonstrated an overall complete response in 40% of cases. Survival
has been improved through this multidisciplinary approach. Patients no
t suitable for surgery obtained important remissions and an improved q
uality of life. Clinical experience at the Istituto Tumori of Milano i
s presented.