USE OF SPECTRAL MAPPING TECHNIQUE FOR THE EVALUATION OF THE FORMATIONOF INCLUSION COMPLEXES BETWEEN ANTICANCER DRUGS AND CYCLODEXTRIN DERIVATIVES

Spectral mapping technique has been used for the separation of the str ength and selectivity of the relative strength of interaction between 18 commercial anticancer drugs and 7 cyclodextrin derivatives. The pot ency values of the spectral map was considered as indicators of the ca pacity of anticancer drugs and cyclodextrins to interact with each oth er taking all the data into consideration simultaneously. The multidim ensional selectivity map was visualized by the two-dimensional nonline ar mapping technique, the iterations was carried out to the point when the difference between the last two iterations was lower than 10(-8). It has been established that both the diameter of the cyclodextrin ca vity and the number and type of substituents on outer sphere of the cy clodextrin molecules influence the complex forming capacity. (C) 1998 Elsevier Science B.V. All rights reserved.