Acquired lesions of the corpus callosum may be related to tumoral, vas
cular, traumatic or degenerative disorders and, one must not forget. f
an result from surgical access. Currently, the quality of neuroimaging
enables a validation or precision of anatomoclinical, neuropsychologi
cal and neurophysiological correlations established from experimental
and/or autopsy data, However the ''specific'' signs of acquired lesion
s of the corpus callosum are often quite complex and may be readily ov
erlooked or masked within a heterogeneous clinical presentation due to
Inure or less important associated lesions of neighboring structures.
Therapeutic management (tumors, arteriovenous malformations. cavernom
as) depend on the nature and the extent of the lesion more than the fu
nctional nature of this interhemispheric commissure with an exceptiona
l functional plasticity, particularly when the lesion is limited.