ADDITION-CYCLIZATION OF 2-HYDROXY-2,3-DIHYDROINDOL-3-ONES WITH ACETYLENECARBOXYLATES - PREPARATION OF FURO[2,3-B]INDOLES

Authors
KAWASAKI T TANG CY KOIZUMI E NAKANISHI H SAKAMOTO M
Citation
T. Kawasaki et al., ADDITION-CYCLIZATION OF 2-HYDROXY-2,3-DIHYDROINDOL-3-ONES WITH ACETYLENECARBOXYLATES - PREPARATION OF FURO[2,3-B]INDOLES, Heterocycles, 48(5), 1998, pp. 975-980
Citations number
31
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
48
Issue
5
Year of publication
1998
Pages
975 - 980
Database
ISI
SICI code
0385-5414(1998)48:5<975:AO2WA>2.0.ZU;2-Y
Abstract
The reaction of 2-hydroxyindol-3-ones (1) with dimethyl acetylenedicar boxylate (2a, DMAD) in the presence of base (triethylamine or sodium c arbonate) underwent Michael addition followed by cyclization to produc e 3a-hydroxyfuro[2,3-b]indoles (3).