REGIOSELECTIVE NUCLEOPHILIC-SUBSTITUTION OF HALOGEN-DERIVATIVES OF 1-SUBSTITUTED 4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACIDS

Authors
HERMECZ I VASVARIDEBRECZY L PODANYI B KERESZTURI G BALOGH M HORVATH A VARKONYI P
Citation
I. Hermecz et al., REGIOSELECTIVE NUCLEOPHILIC-SUBSTITUTION OF HALOGEN-DERIVATIVES OF 1-SUBSTITUTED 4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACIDS, Heterocycles, 48(6), 1998, pp. 1111-1116
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
48
Issue
6
Year of publication
1998
Pages
1111 - 1116
Database
ISI
SICI code
0385-5414(1998)48:6<1111:RNOHO1>2.0.ZU;2-Z
Abstract
The rate of the nucleophilic displacement of the fluoro atom of 7-fluo ro-4-oxo-1,4-dihydroquinoline-3-carboxylate could be enhanced either b y the introduction of further fluoro atom(s) into position(s) 6 and/or 8, or by the formation of a boron chelate (e.g. 3). The regioselectiv ity of the nucleophilic substitution of the chloro atom in 1-substitut ed o-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acids could also be enhanced by the formation of a boron chelate (e.g. 7).