A. Figueras et al., INFLUENCE OF THE SEQUENCE OF ADMINISTRATION OF BETA-GLUCANS AND A VIBRIO-DAMSELA VACCINE ON THE IMMUNE-RESPONSE OF TURBOT (SCOPHTHALMUS-MAXIMUS L.), Veterinary immunology and immunopathology, 64(1), 1998, pp. 59-68
Yeast (Saccharomyces cerevisae) beta-1,3 glucans were used as adjuvant
in a Vibrio damsela vaccine for turbot (Scophthalmus maximus L.). Tur
bot were injected with the adjuvant prior, at the same time and after
the vaccine. Several immune parameters (inder and rate of phagocytosis
, passive haemolytic plaque numbers, and agglutinating antibody titers
) were determined at different times postinoculation. The highest acti
vity of all the immune parameters was obtained when glucans were injec
ted after the bacterin. It is concluded that the sequence of glucan ad
ministration is critical when used as a vaccine adjuvant. (C) 1998 Els
evier Science B.V. All rights reserved.