TRIPLET PHOTOCHEMISTRY OF SUPROFEN IN AQUEOUS ENVIRONMENT AND IN THE BETA-CYCLODEXTRIN INCLUSION COMPLEX

The photodecarboxylation of suprofen in the carboxylate form was studi ed in aqueous medium as a function of the temperature, the concentrati on and the presence of oxygen by steady-state and time-resolved photoc hemical techniques. The process is characterized by an activation ener gy of 9-10 kcal/mol, the precursor state being the lowest triplet whic h is of pi,pi nature. The reactivity of the drug was also studied in the beta-cyclodextrin inclusion complex and an additional photoreactio n involving the macrocycle as reactive species was observed. Represent ative MMR and circular dichroism measurements were performed, Singlet molecular oxygen formation was also investigated.