PROTECTION OF MICE AGAINST PLASMODIUM-YOELII SPOROZOITE CHALLENGE WITH P-YOELII MEROZOITE SURFACE PROTEIN-1 DNA VACCINES

Authors
BECKER SI WANG RB HEDSTROM RC AGUIAR JC JONES TR HOFFMAN SL GARDNER MJ
Citation
Si. Becker et al., PROTECTION OF MICE AGAINST PLASMODIUM-YOELII SPOROZOITE CHALLENGE WITH P-YOELII MEROZOITE SURFACE PROTEIN-1 DNA VACCINES, Infection and immunity, 66(7), 1998, pp. 3457-3461
Citations number
25
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
66
Issue
7
Year of publication
1998
Pages
3457 - 3461
Database
ISI
SICI code
0019-9567(1998)66:7<3457:POMAPS>2.0.ZU;2-M
Abstract
Immunization of mice with DNA vaccines encoding the full-length form a nd C and N termini of Plasmodium yoelii merozoite surface protein 1 pr ovided partial protection against sporozoite challenge and resulted in boosting of antibody titers after challenge. In C57BL/6 mice, two DNA vaccines provided protection comparable to that of recombinant protei n consisting of the C terminus in Freund's adjuvant.