INHIBITION OF CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN-PROCESSING BY ESCHERICHIA-COLI HEAT-LABILE ENTEROTOXIN REQUIRES AN ENZYMATICALLY ACTIVE A SUBUNIT

Authors
MATOUSEK MP NEDRUD JG CIEPLAK W HARDING CV
Citation
Mp. Matousek et al., INHIBITION OF CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN-PROCESSING BY ESCHERICHIA-COLI HEAT-LABILE ENTEROTOXIN REQUIRES AN ENZYMATICALLY ACTIVE A SUBUNIT, Infection and immunity, 66(7), 1998, pp. 3480-3484
Citations number
35
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
66
Issue
7
Year of publication
1998
Pages
3480 - 3484
Database
ISI
SICI code
0019-9567(1998)66:7<3480:IOCMHC>2.0.ZU;2-K
Abstract
Escherichia coil heat-labile enterotoxin (LT) and cholera toxin (CT) w ere found to inhibit intracellular antigen processing. Processing was not inhibited by mutant LT with attenuated ADP-ribosyltransferase acti vity, CT B or LT B subunit, which enhanced presentation of preexisting cell surface peptide-class II major histocompatibility complex comple xes. Inhibition of antigen processing correlated with A subunit ADP-ri bosyltransferase activity.