PRIMARY LIPOSARCOMA OF THE STOMACH - A CASE-REPORT AND A REVIEW OF THE LITERATURE

Primary liposarcoma of the stomach is rare and only seven cases have b een described in the English literature, Here we report the eighth cas e, which occurred in a 68-year-old woman who presented with repeated t arry stools and hematemesis. Endoscopic examination revealed a large u lcerated submucosal mass at the gastric angle. The patient was treated by total gastrectomy. On microscopic examination, the tumor showed th e features of a well differentiated sclerosing liposarcoma, Immunohist ochemically, many spindle to stellate tumor cells were diffusely posit ive for vimentin and CD34, Positivity for S-100 protein was found in t he adipocytic component, including lipoblasts, in addition to some spi ndle-shaped tumor cells. On ultrastructural examination, the spindle t o stellate cells had features characteristic of fibroblasts, No recurr ence or metastasis was seen during 13 months. Liposarcoma of the stoma ch has to be considered in the differential diagnosis with other submu cosal lesions, such as gastric lipoma and gastrointestinal stromal tum or.