DIRECT PHOSPHORYLATION OF N-PROTECTED IMIDAZOLES AND BENZOIMIDAZOLES - A ROUTE TO 1H-IMIDAZOL(BENZOIMIDAZOL)-2-YL PHOSPHONIC AND PHOSPHINICACIDS AND THEIR DERIVATIVES

Authors
KOMAROV IV STRIZHAK AV KORNILOV MY KOSTYUK AN TOLMACHEV AA
Citation
Iv. Komarov et al., DIRECT PHOSPHORYLATION OF N-PROTECTED IMIDAZOLES AND BENZOIMIDAZOLES - A ROUTE TO 1H-IMIDAZOL(BENZOIMIDAZOL)-2-YL PHOSPHONIC AND PHOSPHINICACIDS AND THEIR DERIVATIVES, Synthetic communications, 28(13), 1998, pp. 2355-2370
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
28
Issue
13
Year of publication
1998
Pages
2355 - 2370
Database
ISI
SICI code
0039-7911(1998)28:13<2355:DPONIA>2.0.ZU;2-Q
Abstract
Synthetic approaches to 1H-imidazol-2-yl and 1H-benzoimidazol-2-yl pho sphinic and phosphonic acids and their derivatives are reported, based on phosphorylation of N-protected heterocylcles by PhPOCl2 or MePOCl2 . Reaction of N-alkylbenzoimidazoles with POCl3 did not lead to C-phos phorylated products in a reasonable yield, [2,2']-bis-benzoimidazolyle s being formed instead.