ENDOTHELIAL AND LEUKOCYTE ADHESION MOLECULES IN INFLAMMATION AND DISEASE

Injury associated with ischemia and reperfusion is a significant facto r in a number of clinical diseases. We have completed a number of prec linical studies investigating the blockade of leukocyte adhesion molec ules in ischemia-reperfusion injury. In our work and in the work of ot her investigators, monoclonal antibodies directed to CD18, P-selectin and L-selectin were effective in reducing ischemia-reperfusion injury to the rabbit ear and in reducing injury following hemorrhagic shock i n both rabbits and nonhuman primates. Ischemia-reperfusion injury was also reduced by synthetic oligosaccharide sLe(x). These studies sugges t that adhesion blockade might be effective in the clinical setting.Bl ood Coag Fibrinol9 (suppl 2): S17-S23 (C) 1998 Lippincott-Raven Publis hers.