Js. Schneider et al., PERSISTENT COGNITIVE AND MOTOR DEFICITS FOLLOWING ACUTE HYDROGEN-SULFIDE POISONING, Occupational medicine, 48(4), 1998, pp. 255-260
This case study describes the long-term after-effects of hydrogen sulp
hide exposure in a previously healthy 27-year-old male. Upon hospital
admission the patient had a Glasgow Coma Score (CGS) of 3; with emerge
ncy treatment including hyperbaric oxygen treatments, he progressed to
a GCS of 15 on day 7. Although both CT and MRI scans were unremarkabl
e, PET using F-18 deoxyglucose administered 3 years after the accident
showed abnormally decreased metabolism bilaterally in the temporal an
d inferior parietal lobes as well as the left thalamus. Uptake in the
striatum was heterogeneous and abnormal. A cerebral perfusion study us
ing SPECT performed 3.5 years after the accident revealed bilaterally
decreased flow in the putamen but no cortical abnormalities. Neuropsyc
hological and neurofunctional testing revealed the following impairmen
ts: microsmia, psychomotor slowing, extrapyramidal signs and deficits
in memory and executive/planning functioning. These findings are discu
ssed in the context of hydrogen sulphide's known mechanisms of toxicit
y and the functions of the basal ganglia.