SYSTEMIC ANTIBIOTIC-PROPHYLAXIS IN ELECTIVE CESAREAN DELIVERY

Objective: To test the value of using prophylactic antibiotics at elec tive cesarean delivery. Method: One-hundred and twenty women delivered by elective cesarean in the absence of labor and before the rupture o f membranes were randomized to receive either 1.5 g of cefuroxime intr avenously at cord clamping (n = 59) or no prophylaxis (control group, n = 61). Results. Twelve women developed febrile morbidity (six study, six control, P = 0.09). Of these, five had endometritis (two study, t hree control, P = 0.09) and two had wound infection (one study, one co ntrol, P = 0.09). Ten more women had microbiological evidence of endom etritis and wound infection (six study, four control, P = 0.08). There was no significant difference in the hospital stay (6.5 days study, 6 .8 days control, P = 0.06). Staphylococcus aureus was the commonest pa thogen accounting for 14 infection episodes. Amniotic fluid culture co uld not predict the development of infection. Conclusion: Administrati on of prophylactic antibiotics at elective cesarean deliveries was not associated with decreased postoperative morbidity. (C) 1998 Internati onal Federation of Gynecology and Obstetrics.