RELEASE OF A SUBSTANCE THAT SUPPRESSES SPONTANEOUS MOTOR-ACTIVITY IN THE BRAIN BY PHYSICAL EXERCISE

Authors
INOUE K YAMAZAKI H MANABE Y FUKUDA C FUSHIKI T
Citation
K. Inoue et al., RELEASE OF A SUBSTANCE THAT SUPPRESSES SPONTANEOUS MOTOR-ACTIVITY IN THE BRAIN BY PHYSICAL EXERCISE, Physiology & behavior, 64(2), 1998, pp. 185-190
Citations number
12
Categorie Soggetti
Psychology, Biological","Behavioral Sciences
Journal title
Physiology & behavior → ACNP
ISSN journal
00319384
Volume
64
Issue
2
Year of publication
1998
Pages
185 - 190
Database
ISI
SICI code
0031-9384(1998)64:2<185:ROASTS>2.0.ZU;2-O
Abstract
Injection of the cerebrospinal fluid (CSF) collected from rats fatigue d by obligatory swimming into the cisterna magna of mice suppressed th e spontaneous motor activity of the mice. The suppressive activity was abolished by heat denaturation of the CSF and was found in the CSF fr action with a molecular weight above 10,000 after ultrafiltration. The se findings suggest the presence of a substance(s) released in a fatig ued animal's brain that suppresses its spontaneous motor activity and generates the sensation of fatigue, (C) 1998 Elsevier Science Inc.