It. Paulsen et al., CHARACTERIZATION OF THE EARLIEST KNOWN STAPHYLOCOCCUS-AUREUS PLASMID ENCODING A MULTIDRUG EFFLUX SYSTEM, Journal of bacteriology, 180(13), 1998, pp. 3477-3479
The staphylococcal qacB-encoding multidrug resistance plasmid pSK156,
isolated from a clinical strain dating from 1951, was characterized. C
omparison of the regions flanking qacB with other qacB and qacB-encodi
ng plasmids provided insights into the evolution and dissemination of
these multidrug efflux genes and led to the detection of the earliest
known copy of the insertion sequence IS257.