GENERAL STRATEGIES TOWARD THE SYNTHESES OF MACROLIDE ANTIBIOTICS - THE TOTAL SYNTHESES OF 6-DEOXYERYTHRONOLIDE-B AND OLEANDOLIDE

Authors
EVANS DA KIM AS METTERNICH R NOVACK VJ
Citation
Da. Evans et al., GENERAL STRATEGIES TOWARD THE SYNTHESES OF MACROLIDE ANTIBIOTICS - THE TOTAL SYNTHESES OF 6-DEOXYERYTHRONOLIDE-B AND OLEANDOLIDE, Journal of the American Chemical Society, 120(24), 1998, pp. 5921-5942
Citations number
76
Categorie Soggetti
Chemistry
Journal title
Journal of the American Chemical Society → ACNP
ISSN journal
00027863
Volume
120
Issue
24
Year of publication
1998
Pages
5921 - 5942
Database
ISI
SICI code
0002-7863(1998)120:24<5921:GSTTSO>2.0.ZU;2-9
Abstract
The asymmetric syntheses of 6-deoxyerythronolide B (1) and oleandolide (2) have been achieved, each in 18 linear steps. These syntheses demo nstrate the utility of chiral beta-keto imide building block 3 as a ve rsatile building block for the aldol-based assemblage of polypropionat e-derived natural products.