PHASE-TRANSFER-CATALYZED ALKYLATION OF 2-(DIETHOXYPHOSPHINYL)CYCLOHEXANONE

Authors
RUDER SM KULKARNI VR
Citation
Sm. Ruder et Vr. Kulkarni, PHASE-TRANSFER-CATALYZED ALKYLATION OF 2-(DIETHOXYPHOSPHINYL)CYCLOHEXANONE, Synthesis, (10), 1993, pp. 945-947
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
10
Year of publication
1993
Pages
945 - 947
Database
ISI
SICI code
0039-7881(1993):10<945:PAO2>2.0.ZU;2-Y
Abstract
Alkylation of cyclic beta-oxophosphonates using the ion pair extractiv e-phase transfer catalysis method was studied using 2-(diethoxyphosphi nyl)cyclohexanone as the model compound. Unlike related phosphonic aci d derivatives, the cyclic beta-oxophosphonates exhibited ambident char acter under phase transfer conditions when dichloromethane was used as the solvent. Carbon alkylation was most effective when activated and sterically less demanding alkyl halides were utilized.