SYNTHESIS OF 3,3-DIFLUORO-DL-ALANINE AND 3,3-DIFLUORO-DL-ALANINE PRECURSORS

Authors
DORCHYMONT H
Citation
H. Dorchymont, SYNTHESIS OF 3,3-DIFLUORO-DL-ALANINE AND 3,3-DIFLUORO-DL-ALANINE PRECURSORS, Synthesis, (10), 1993, pp. 961-963
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
10
Year of publication
1993
Pages
961 - 963
Database
ISI
SICI code
0039-7881(1993):10<961:SO3A3P>2.0.ZU;2-H
Abstract
The key intermediate to 3,3-difluoroalanine, 2,2-difluoro-1-ethyl-thio ethylamine hydrobromide (2), was prepared by the Steglich and Weygand procedure. Its conversion to benzyloxycarbonyl-2,2-difluoro-1-ethenyle thylamine (5) followed by oxidation and subsequent deprotection of the amine afforded the 3,3-difluoroalanine.