FUNGICIDAL ACTIVITIES OF 2-(SUBSTITUTED PHENOXYMETHYL)PHENYL-2-METHOXYIMINOACETAMIDE DERIVATIVES

A number of 2-(substituted phenoxymethyl)phenyl-2-methoxy iminoacetami des were synthesized and their fungicidal activities were examined. Th e strength of activities and fungicidal spectra varied markedly depend ing upon the substituents on the benzene ring of the 2-phenoxymethyl g roup of phenylacetamide moiety. Incorporation of either one or two sub stituent(s) at 2-, 3-, 4- and/or 5-positions on the benzene ring resul ted in an increase of fungicidal activity compared to the unsubstitute d compound. However, introduction of a bulky substituent at the 2-posi tion or simultaneous substitution at 2- and 6-positions resulted in de crease of activity. When 2- and 4-, or 2- and 5-positions of the benze ne ring were substituted with chlorine and/or methyl groups, in additi on to the 2,5-difluoro derivative (30), the activities were excellent against wheat powdery mildew, cucumber powdery mildew, cucumber gray m old and cucumber downy mildew. Between the two geometrical isomers, th e E-form was much stronger than the Z-form.