SYNTHESIS OF ALPHA,ALPHA-DISUBSTITUTED-ALPHA-AMINO ACIDS BY DOUBLE NUCLEOPHILIC-ADDITION TO CYANOHYDRINS

Authors
CHARETTE AB GAGNON A JANES M MELLON C
Citation
Ab. Charette et al., SYNTHESIS OF ALPHA,ALPHA-DISUBSTITUTED-ALPHA-AMINO ACIDS BY DOUBLE NUCLEOPHILIC-ADDITION TO CYANOHYDRINS, Tetrahedron letters, 39(29), 1998, pp. 5147-5150
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
29
Year of publication
1998
Pages
5147 - 5150
Database
ISI
SICI code
0040-4039(1998)39:29<5147:SOAABD>2.0.ZU;2-T
Abstract
The synthesis of tertiary carbinamines was achieved by the double nucl eophilic addition of Grignard reagents to cyanohydrins. Titanium isopr opoxide was found to promote the process. In a typical example, the ra pid conversion of a carbinamine to the corresponding alpha,alpha-disub srituted-alpha-amino acid was also demonstrated. (C) 1998 Elsevier Sci ence Ltd. All rights reserved.