OPPA ESCHERICHIA-COLI MUTANTS HAVE OSMODEPENDENT RESISTANCE TO AMINOGLYCOSIDE ANTIBIOTICS

Authors
TSUHAKO HH FERREIRA LCS DACOSTA SOP
Citation
Hh. Tsuhako et al., OPPA ESCHERICHIA-COLI MUTANTS HAVE OSMODEPENDENT RESISTANCE TO AMINOGLYCOSIDE ANTIBIOTICS, GENETICS AND MOLECULAR BIOLOGY, 21(1), 1998, pp. 15-19
Citations number
22
Categorie Soggetti
Genetics & Heredity
Journal title
GENETICS AND MOLECULAR BIOLOGY → ACNP
ISSN journal
14154757
Volume
21
Issue
1
Year of publication
1998
Pages
15 - 19
Database
ISI
SICI code
1415-4757(1998)21:1<15:OEMHOR>2.0.ZU;2-N
Abstract
The oligopeptide permease (OppA) protein was found to be missing in th e periplasmic fractions of Escherichia coli kanamycin-resistant mutant s selected under high osmotic conditions. The growth behavior of one m utant in media containing kanamycin or the toxic peptide triornithine suggests that OppA and another cell envelope component contribute to t he osmolarity-dependent aminoglycoside resistance of E. coli.