CORRELATION BETWEEN ANTERIOR-CHAMBER IGG ALBUMIN CONCENTRATIONS AND LASER FLARE PHOTOMETRY IN EYES WITH ENDOGENOUS UVEITIS/

Purpose: To assess the correlation between laser flare measurements an d anterior chamber IgG/albumin concentrations in eyes with mild to sev ere inflammation. Materials and Methods: Seventeen eyes of 17 patients with endogenous uveitis underwent diagnostic paracentesis. IgG and al bumin concentrations were determined from the samples of aqueous humor . Laser flare measurements were performed Ih prior to paracentesis. Th e relationship between flare measurements and IgG/albumin concentratio ns was studied be plotting the data on a logarithmic scale. Results: T he flare measurement was 97.5+/-150.0 photons ms (mean +/- SD; range 4 .3-528.7). The IgG concentration was 41.0+/-51.4 mg/dl (mean +/- SD; r ange 0.2-200). The albumin concentration was 184.6+/-196.2 mg/dl (mean +/- SD; range 4-535). When plotted on a logarithmic scale, there was a statistically significant linear relationship between the flare meas urements and the anterior chamber IgG or albumin concentrations (y = 1 .14x-0.64, r = 0.87 p < 0.001 for IgG; y = 1.39x-0.1, r = 0.94, p < 0. 001 for albumin). Conclusion: Laser flare photometry is an accurate te chnique for assessing anterior chamber inflammation. Flare measurement s strongly correlate with blood-aqueous barrier breakdown.