The concept of the threshold of therapeutic intervention as a function
of the absolute risk is introduced. The definitions of relative risk
and absolute risk are then recalled; in the case of absolute risk, onl
y prolonged observation of a cohort combined with multivariate statist
ical analysis can select the most relevant risk factors and attribute
a relative weighting to each factor. Software may be helpful. The role
s of the age high-risk productions, their lifestyle, modalities of the
rapeutic intervention, and economic implications are discussed.