RAPID ENANTIOSELECTIVE ACCESS TO DES-AB-TRIENIC CORTICOSTEROIDS VIA INTRAMOLECULAR CYCLOADDITION

Authors
NEMOTO H SATOH A FUKUMOTO K
Citation
H. Nemoto et al., RAPID ENANTIOSELECTIVE ACCESS TO DES-AB-TRIENIC CORTICOSTEROIDS VIA INTRAMOLECULAR CYCLOADDITION, Journal of the Chemical Society. Perkin transactions. I, (19), 1993, pp. 2237-2238
Citations number
46
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
19
Year of publication
1993
Pages
2237 - 2238
Database
ISI
SICI code
0300-922X(1993):19<2237:REATDC>2.0.ZU;2-6
Abstract
A short synthesis of an enantiomerically pure des-AB-trienic steroid 1 1 has been achieved by thermolysis of the optically active alkenic ben zocyclobutene 9 obtained by selective nucleophilic addition of an isop ropenyl group to the chiral epoxide 5 as a key step.