Canine distemper virus (CDV) has been implicated in some recent deaths
of lions, which showed clinical signs of distemper, in the the Sereng
eti plain. Similar clinical findings have since been reported in lions
of the Masai Mara. Fifty-five per cent of serum samples obtained from
wild lions of the Masai Mara have been found to contain neutralising
antibody to CDV, indicating that they had been exposed to the virus. A
dult orphan lions kept in captivity, were vaccinated with the live att
enuated Onderstepoort strain of CDV, The results indicated that the va
ccine is both safe and immunogenic, and may be potentially useful for
the prophylactic vaccination of lions at high risk.