THE TOXICITY OF SEED EXTRACTS AND THEIR FRACTIONS FROM LUPINUS-ANGUSTOFOLIUS L AND LUPINUS-ALBUS L

Seed extracts obtained from Lupinus albus and LuPinus angustifolius by treatment with 48% ethanol contained ca. 10% alkaloids (on a dry weig ht basis) and were non-toxic. Their acute toxicity (LD50) in the mouse is > 4000 mg kg-1 body wt. After fractionation, the extract from L. a ngustifolius seeds afforded several fractions with differing toxicitie s (LD50 750-4000 mg kg-1 body wt.). None of the fractions tested in vi tro were toxic. The results obtained showed that, in spite of the alka loids, other low-molecular-weight constituents present significantly m odified the toxicity of the lupin extracts.