CRYSTALLIZATION OF PIRATOXIN-I, A MYOTOXIC LYS49-PHOSPHOLIPASE A(2) HOMOLOG ISOLATED FROM THE VENOM OF BOTHROPS PIRAJAI

Authors
CANDURI F MANCUSO LC SOARES AM GIGLIO JR WARD RJ ARNI RK
Citation
F. Canduri et al., CRYSTALLIZATION OF PIRATOXIN-I, A MYOTOXIC LYS49-PHOSPHOLIPASE A(2) HOMOLOG ISOLATED FROM THE VENOM OF BOTHROPS PIRAJAI, Toxicon (Oxford), 36(3), 1998, pp. 547-551
Citations number
30
Categorie Soggetti
Toxicology,"Pharmacology & Pharmacy
Journal title
Toxicon (Oxford) → ACNP
ISSN journal
00410101
Volume
36
Issue
3
Year of publication
1998
Pages
547 - 551
Database
ISI
SICI code
0041-0101(1998)36:3<547:COPAML>2.0.ZU;2-P
Abstract
Fernanda Canduri, Lit C. Mancuso, Andreimar M. Soares, Jose R. Giglio, Richard J. Ward and Raghuvir K. Arni. Crystallization of piratoxin I, a myotoxic Lys49-phospholipase A(2) homologue isolated from the venom of Bothrops pirajai. Toxicon 36, 547-551, 1998.-Large single crystals of piratoxin I, a Lys49-PLA(2) homologue with low enzymatic activity, have been obtained. The crystals belong to the orthorhombic system sp ace group p2(1)2(1)2(1) and diffract X-raps to a resolution of 2.8 Ang strom. Preliminary analysis reveals the presence of two molecules in t he crystallographic asymmetric unit. (C) 1998 Elsevier Science Ltd. Al l rights reserved.