STUDIES ON THE STABILITY OF 1,7,9-TRIOXADISPIRO[5.1.5.2]PENTADECANE SYSTEM - THE COMMON TRICYCLIC ACETAL MOIETY IN PINNATOXINS

Authors
ISHIHARA J SUGIMOTO T MURAI A
Citation
J. Ishihara et al., STUDIES ON THE STABILITY OF 1,7,9-TRIOXADISPIRO[5.1.5.2]PENTADECANE SYSTEM - THE COMMON TRICYCLIC ACETAL MOIETY IN PINNATOXINS, Synlett, (6), 1998, pp. 603
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
6
Year of publication
1998
Database
ISI
SICI code
0936-5214(1998):6<603:SOTSO1>2.0.ZU;2-A
Abstract
The stability of the common dispiroacetal moiety in pinnatoxins, the 1 ,7,9-trioxadispiro[5.1.5.2]pentadecane system. was investigated. The t ricyclic keto acetal, of the natural form, was most favored among the possible isomers, however, its methylated form was not so preferential to be isomerized readily in the presence of acid. These stability res ults were supported by MM2 and AM1.