CONFORMATIONAL CONTROL IN PROTON SOURCES FOR ENANTIOSELECTIVE PROTONATION OF SAMARIUM ENOLATE DERIVED FROM ALPHA-METHOXY-SUBSTITUTED KETONES

Authors
MIKAMI K YAMAOKA M YOSHIDA A NAKAMURA Y TAKEUCHI S OHGO Y
Citation
K. Mikami et al., CONFORMATIONAL CONTROL IN PROTON SOURCES FOR ENANTIOSELECTIVE PROTONATION OF SAMARIUM ENOLATE DERIVED FROM ALPHA-METHOXY-SUBSTITUTED KETONES, Synlett, (6), 1998, pp. 607
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
6
Year of publication
1998
Database
ISI
SICI code
0936-5214(1998):6<607:CCIPSF>2.0.ZU;2-W
Abstract
High enantioselectivity is achieved in the asymmetric protonation of s amarium enolate, regioselectively generated by SmI2-mediated reduction of 2-methoxy-substituted cyclohexanones using achiral diamine- or pro -atropisomeric 2,2'-biphenol-derived chiral diols as proton sources by virtue of the conformational control.