PD-MEDIATED C-C AND CS BOND FORMATION ON SOLID SUPPORT - A SCOPE AND LIMITATIONS STUDY

The scope and limitations of Pd(0)-mediated coupling reactions between aromatic halides linked to a polystyrene resin and boronic acid deriv atives (Suzuki coupling), aromatic and vinylic tin compounds (Stille c oupling), as well as thiols are reported. For all reactions, condition s were optimized and evaluated with various reagents. In many cases, u pon cleavage from the solid support, products were obtained in excelle nt yields. In most cases, the optimized reaction conditions are superi or to those previously reported in the literature.