K1115, A NEW ANTHRAQUINONE DERIVATIVE THAT INHIBITS THE BINDING OF ACTIVATOR PROTEIN-1 (AP-1) TO ITS RECOGNITION SITES - I - BIOLOGICAL-ACTIVITIES

K1115 A, a new anthraquinone derivative, was isolated from the culture broth of Streptomyces griseorubiginosus (Mer-K1115), K1115A inhibited the direct binding of activator protein-1 (AP-1) to AP-1 oligonucleot ide (IC50 = 100 mu M), and the production of collagenase in IL-1 alpha -stimulated rat synovial cells (IC50 = 60 mu M). In vivo, the applicat ion of K1115 A decreased phorbol myristate acetate (PMA)-induced mouse ornithine decarboxylase (ODC) activity. These results indicated that K1115 A is able to attenuate the inflammatory response mediated by AP- 1.