TREATMENT OF CHRONIC MYELOID-LEUKEMIA IN RELAPSE AFTER UMBILICAL-CORDBLOOD TRANSPLANTATION

Umbilical cord blood (UCB) is increasingly used as a source of hematop oietic progenitor cells for allotransplantation. Donor-derived buffy c oat cells are considered optimal treatment for leukemia relapses after transplantation of allogeneic bone marrow. Experience with relapses a fter UCB transplants are sparse. Here we report a girl who received an UCB transplant for chronic myeloid leukemia, relapsed after three yea rs, failed to respond to donor huffy coat cells, but achieved a comple te hematologic, cytogenetic, and molecular remission on interferon-alp ha.