GASTRIC-EMPTYING OF RADIONUCLIDE-LABELED SOLID MEAL IN BEAGLE DOGS USING A SCINTIGRAPHIC METHOD

A scintigraphic method for in vivo radiotracers measurement is describ ed to investigate the gastrointestinal emptying rate in beagle dogs. T he proposed method has been applied to study the effect of a pharmacol ogical compound in enhancing stomach emptying and involves the followi ng steps: 1) I-131-labeled anion exchange resin grains preparation, as solid food markers to be ingested by the dogs; 2) continous recording of gastric emptying evolution over a period of 5 h with fast data-gat hering instrumentation employing small size and light-weight CsI scint illation detectors coupled to a photodiode, equipped with a lead shiel d and collimator; 3) comparison of results obtained with drugs to prev ious standard emptying curves. The purpose of this study was to evalua te the prokinetic activity of a recent synthesized compound (BIMU 1).