EFFICACY OF 2 DIFFERENT INTRAMUSCULAR DOSES OF DIPYRONE IN ACUTE RENAL COLIC

A randomized multicenter clinical trial was designed to compare the ef ficacy and tolerance of two different intramuscular doses of dipyrone (I g and 2 g) with those of the reference drug, diclofenac sodium (75 mg), in the treatment of acute renal colic. A total of 129 patients we re included, 43 patients were alloted to receive dipyrone 1 g, 45 to d ipyrone 2 g, and 41 to diclofenac. Evaluation of pain (100 mm visual a nalogue scale) was carried out at 10, 20, 30, 60 min and 2, 4 and 6 h after drug administration. There were no significant differences betwe en the three groups in terms of pain relief in the first 60 min, but d ipyrone 2 g provided significantly more pain relief than diclofenac an d dipyrone 1 g from 60 min to 6 h after drug injection. It is conclude d that dipyrone 2 g produced a longer lasting analgesic response than dipyrone 1 g in the treatment of renal colic.