LEPTIN INHIBITION OF INSULIN-SECRETION FROM ISOLATED HUMAN ISLETS

Citation
Hc. Fehmann et al., LEPTIN INHIBITION OF INSULIN-SECRETION FROM ISOLATED HUMAN ISLETS, Acta diabetologica, 34(4), 1997, pp. 249-252
Citations number
35
Journal title
ISSN journal
09405429
Volume
34
Issue
4
Year of publication
1997
Pages
249 - 252
Database
ISI
SICI code
0940-5429(1997)34:4<249:LIOIFI>2.0.ZU;2-D
Abstract
Leptin is a hormone produced and secreted from the adipose tissue. Its physiological actions include the regulation of satiety, food intake and energy balance, The production of leptin is increased by high insu lin levels. Here, we demonstrate that leptin acts as an inhibitor of g lucose-induced (20 mM) insulin secretion from isolated human islets. N o effect was observed in the presence of lower glucose levels (2.8 and 10 mM glucose). The pancreatic beta-cell might represent a target of a direct physiological action of leptin, We suggest the presence of an ''adipo-insular axis'' in which leptin mediates negative feedback fro m the adipose tissue to the endocrine pancreas.