DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF MAGNESIUM-HYDROXIDE FOR TREATMENT OF SENSORY URGENCY AND DETRUSOR INSTABILITY - PRELIMINARY-RESULTS

In a prospective, randomised, double-blind, placebo-controlled study 4 0 women with sensory urgency or detrusor instability randomly received either magnesium hydroxide (group A) or placebo (group B). Pre- and p ost-treatment symptoms, frequency-volume charts and cystometry results were compared. Eleven of 20 patients receiving magnesium (55%) report ed a subjective improvement of their urinary symptoms, compared with f ive patients taking placebo (20%). In both study groups there was no s tatistically significant difference in pre- and post-treatment urodyna mic parameters in those reporting symptomatic improvement. Magnesium w as well tolerated by patients in group A, and no side effects were rep orted. These results suggest that magnesium hydroxide may be beneficia l for detrusor instability or sensory urgency in women.