RETINOIC ACID AND INTERFERON COMBINATION STUDIES IN HUMAN CANCER

Retinoic acid and interferon-alpha have limited single-agent activity in advanced cancer. Cell culture data indicate that in combination the se agents have enhanced activity (modulating growth and differentiatio n) in a number of malignant cell types. Recent clinical work in advanc ed squamous cell carcinoma reports major activity with this regimen. T his paper reviews the preclinical and clinical data testing retinoic a cid in combination with interferons and presents recent work integrati ng these agents with radiotherapy in locally advanced cervical cancer.