CONFIRMATORY ANALYSIS OF CLENBUTEROL USING 2 DIFFERENT DERIVATIVES SIMULTANEOUSLY

To meet the requirements of the European Community for confirmatory an alysis of clenbuterol using low-resolution mass spectrometry usually t wo different techniques (i.e. electron impact and chemical ionization) have to be applied to confirm unambiguously its presence in extracts of urine. This paper describes the application of two different deriva tives and the simultaneous analysis of these two different derivatives in one gas chromatographic-mass spectrometric analysis. With the prop osed combination of techniques, Community requirements can more easily be met in only one analytical run. Examples of the analysis of some u rine samples are presented, as well as data on linearity, repeatabilit y and equivalence of the combined technique to separate determinations .