EFFECTS OF BETA-AMYLOID PEPTIDE ON TRANSIENT OUTWARD POTASSIUM CURRENT OF ACUTELY DISSOCIATED HIPPOCAMPAL-NEURONS IN CA(1) SECTOR IN RATS

Authors
XU CQ QIAN CY ZHANG ZM WU CH ZHOU PA LIANG XL
Citation
Cq. Xu et al., EFFECTS OF BETA-AMYLOID PEPTIDE ON TRANSIENT OUTWARD POTASSIUM CURRENT OF ACUTELY DISSOCIATED HIPPOCAMPAL-NEURONS IN CA(1) SECTOR IN RATS, Chinese medical journal, 111(6), 1998, pp. 492-495
Citations number
10
Categorie Soggetti
Medicine, General & Internal
Journal title
Chinese medical journal → ACNP
ISSN journal
03666999
Volume
111
Issue
6
Year of publication
1998
Pages
492 - 495
Database
ISI
SICI code
0366-6999(1998)111:6<492:EOBPOT>2.0.ZU;2-4
Abstract
Objective To explore the mechanism of beta-amyloid peptide (beta-AP) i n Alzheimer's disease at ionic channel level. Methods Hippocampal CA(1 ) neurons of 7-21 days' rats were acutely dissociated and the effects of beta-AP on transient outward potassium current were observed by a w hole-cell recording patch clamp technique. Results beta-AP can signifi cantly block transient potassium current in dose-dependent, time-depen dent and partly voltage-dependent manners. Conclusion beta-AP may decr ease the membrane conductance of K+ channels in hippocampal neurons, p laying an important role in the pathophysiological mechanism of Alzhei mer's disease.