TOTAL SYNTHESIS OF BALANOL - A POTENT PROTEIN-KINASE-C INHIBITOR OF FUNGAL ORIGIN

Authors
ADAMS CP FAIRWAY SM HARDY CJ HIBBS DE HURSTHOUSE MB MORLEY AD SHARP BW VICKER N WARNER I
Citation
Cp. Adams et al., TOTAL SYNTHESIS OF BALANOL - A POTENT PROTEIN-KINASE-C INHIBITOR OF FUNGAL ORIGIN, Journal of the Chemical Society. Perkin transactions. I, (18), 1995, pp. 2355-2362
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
18
Year of publication
1995
Pages
2355 - 2362
Database
ISI
SICI code
0300-922X(1995):18<2355:TSOB-A>2.0.ZU;2-E
Abstract
The total synthesis of the fungal metabolite balanol, a potent inhibit or of protein kinase C, is described. The synthesis includes a novel s ynthesis of 3-amino-4-hydroxyazepanes via a directed ring expansion of 3-bromopiperidin-4-ones.