THROMBOTIC MICROANGIOPATHY OF HYPERACUTE ONSET AFTER AUTOLOGOUS PERIPHERAL-BLOOD STEM-CELL TRANSPLANTATION IN MALIGNANT-LYMPHOMA

Bone marrow transplant-associated thrombotic microangiopathy (BMT-TM), usually associated with thrombocytopenia, microangiopathic haemolytic anaemia (MAHA) and renal insufficiency, has been reported to occur ap proximately 5-6 months after BMT, We report a case of relapsed maligna nt lymphoma complicated by BMT-TM of hyperacute onset, which has never been described in the literature. Our patient, a 52-year-old male, de veloped MAHA with gross haematuria, thrombocytopenia, lactate dehydrog enase elevation and renal insufficiency 2 days after autologous PBSC t ransplantation following high-dose chemotherapy, Supportive treatment, ie glucocorticoid, fresh frozen plasma and haemodiafiltration were gi ven, and thereafter the BMT-TM gradually improved. In heavily pretreat ed patients, caution should be exercised for possible occurrence of th e BMT-TM of hyperacute onset.