CENTRAL-NERVOUS-SYSTEM RECEPTOR-BINDING PROFILES OF SOME 2-AMINO-4-PHENYL QUINOLINES - A NOVEL CLASS OF ALPHA(2)-ADRENOCEPTOR SELECTIVE LIGANDS

Authors
NICHOLLS IA MORRISON SF BRINKWORTH RI ALEWOOD PF ANDREWS PR
Citation
Ia. Nicholls et al., CENTRAL-NERVOUS-SYSTEM RECEPTOR-BINDING PROFILES OF SOME 2-AMINO-4-PHENYL QUINOLINES - A NOVEL CLASS OF ALPHA(2)-ADRENOCEPTOR SELECTIVE LIGANDS, Life sciences, 53(20), 1993, pp. 343-347
Citations number
22
Categorie Soggetti
Biology,"Medicine, Research & Experimental
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
53
Issue
20
Year of publication
1993
Pages
343 - 347
Database
ISI
SICI code
0024-3205(1993)53:20<343:CRPOS2>2.0.ZU;2-N
Abstract
The 2-amino-4-phenyl quinoline moiety is a structural motif common to a number of central nervous system active agents. Extensive radio-liga nd receptor binding profiles for several derivatives of this common st ructural feature have been determined. A high base level of central ne rvous system receptor affinity was observed with a distinct preference for the alpha-, and in particular the alpha2-, adrenoceptors.