DISEASES OF G-PROTEIN-COUPLED SIGNAL-TRANSDUCTION PATHWAYS - THE MAMMALIAN VISUAL-SYSTEM AS A MODEL

G-protein-coupled signaling systems play a role in a diversity of norm al physiological functions. Logically, one might predict that mutation s in genes encoding any one of the G-protein subunits, G-protein-coupl ed receptors, or effector proteins of a given signaling pathway could lead to disease. Mutations of G-protein-coupled signaling proteins kno wn to cause human diseases are reviewed here, with a primary emphasis on the mammalian phototransduction system. (C) 1998 Academic Press.