CHIMANINES, NEW 2-SUBSTITUTED QUINOLINES, ISOLATED FROM AN ANTIPARASITIC PLANT IN BOLIVIA - GALIPEA-LONGIFLORA

Petroleum ether and CHCl3 extracts of stem, root bark, and leaves of G alipea longiflora were found active in vitro against Leishmania sp. an d Trypanosoma cruzi at 100 mug/ml. The activity-guided fractionation o f the extracts by chromatography afforded thirteen active compounds id entified as 2-substituted quinoline alkaloids. Four new 2-alkylquinoli ne alkaloids were isolated and identified from leaves or trunk bark of G. longiflora: 4-methoxy-2-n-propylquinoline [10] (chimanine A), 2-(E )-prop-1'-enylquinoline [11] (chimanine B), 4-methoxy-2-(E)-prop-1'-en ylquinoline [12] (chimanine C), and 2-(1',2'-trans-epoxypropyl)-quinol ine [13] (chimanine D). These alkaloids are accompanied by eight known 2-substituted quinolines (2-9), and by one known furo-(2,3b)-quinolin e alkaloid, skimmianine [1].