H. Enomoto et al., TOPOGRAPHIC DISTRIBUTION OF HELICOBACTER-PYLORI IN THE RESECTED STOMACH, European journal of gastroenterology & hepatology, 10(6), 1998, pp. 473-478
Objectives The aim of this study was to elucidate the prevalence of He
liobacter pylori and its distribution in order to clarify the frequenc
y of H. pylori infection and the most appropriate site of endoscopic b
iopsy for studies of H. pylori infection associated with different gas
tric diseases. Designs and methods Swiss role mucosal strips from 275
resected stomachs, which included the greater curvature, anterior wall
and lesser curvature of the antrum, incisura and corpus, were stained
with haematoxylin-eosin and H. pylori antibody. Results The prevalenc
e of H. pylori infection was 97% in duodenal ulcers, 98% in gastric ul
cers, 98% in intestinal-type carcinomas and 99% in diffuse-type carcin
omas. H. pylori was present at a rate of 100% in any sire in cases of
duodenal ulcer, but was diffusely distributed in the antrum and patchi
ly distributed in the corpus, The detection rate of H. pylori was 50-1
00% in gastric ulcers, 30-100% in intestinal-type adenocarcinomas and
63-100% in diffuse-type adenocarcinomas depending on the site of the s
tomach examined. Conclusions The prevalence of H. pylori infection was
very high in peptic ulcers of the duodenum and stomach and gastric ca
rcinomas of Japanese patients. Biopsy specimens for evaluation of H. p
ylori infection should be taken routinely from both the greater curvat
ure of the antrum and corpus. Immunohistochemical staining should be u
sed to assay for ii pylori when few organisms are present or eradicati
on therapy has been used. Eur J Gastroenterol Hepatol 10:473-478 (C) 1
998 Lippincott-Raven Publishers.