DIFFERENTIAL-EFFECTS OF BODY FATNESS AND BODY-FAT DISTRIBUTION ON RISK-FACTORS FOR CARDIOVASCULAR-DISEASE IN WOMEN - IMPACT OF WEIGHT-LOSS

This study examines the role of obesity and body fat distribution (ie, waist-to-hip ratio [WHR]) on cardiovascular disease (CVD) risk factor s in 50 nondiabetic, obese (body mass index [BMI], 31 +/- 2 kg/M2, mea n +/- SD), 45 +/- 10-year-old women. The data obtained at baseline and after weight loss were analyzed after dividing subjects by WHR into u pper-body (WHR >0.80) and lower-body (WHR less-than-or-equal-to 0.80) groups and by median-split BMI into more obese (BMI greater-than-or-eq ual-to 31) and less obese (BMI <31) groups. At baseline, the upper-bod y obese women, when compared with lower-body obese women, had higher p lasma triglycerides (TGs) (175 +/- 85 versus 111 +/- 47 mg/dL, respect ively; P<.001) and lower high-density lipoprotein cholesterol (HDL-C) (44 +/- 10 versus 54-11, respectively; P<.01) but similar total and lo w-density lipoprotein cholesterol levels and blood pressure. There wer e no significant differences in these CVD risk factors at baseline by BMI split. Although weight loss (-9 +/- 5 kg) lowered blood pressure a nd TGs irrespective of WHR or BMI, only upper-body obese women raised HDL-C. Moreover, the magnitude of the changes was greatest in women wi th an upper-body fat distribution. In women with WHR >0.80, HDL-C incr eased by 11%, to 49 mg/dL (P<.001), and TGs decreased by 24%, to 134 m g/dL (P<.001). The increase in HDL-C with weight loss was predicted in a linear model by the initial WHR, whereas the reductions in TGs and blood pressure were predicted by the change in body weight. Thus, an u pper-body fat distribution in women worsens the lipid risk factors for CVD posed by obesity, and weight loss is an effective intervention to improve lipid profiles in these women. Although weight loss improved CVD risk factors regardless of BMI or WHR, the magnitude of the increa se in plasma HDL-C and decrease in TGs in women with an upper-body fat distribution suggests that weight loss in these women has the greates t potentiality of reducing their risk factors for CVD.