Echogenic fluid is an important extrauterine finding of ectopic pregna
ncy. The purpose of this study was to determine how accurately echogen
ic fluid correlates with hemoperitoneum at surgery Transvaginal sonogr
aphy was performed in 831 consecutive patients referred to rule out ec
topic pregnancy over a 36 month period. Scans were retrospectively eva
luated for the presence or absence and echogenicity of free pelvic flu
id. Subsequently, 185 patients had a laparotomy or laparoscopy and had
documentation of the presence or absence of hemoperitoneum. On transv
aginal sonography 125 patients had echogenic fluid, 30 patients had an
echoic fluid, and 30 patients had no fluid. Of the 125 patients with e
chogenic fluid, 122 (98%) patients had hemoperitoneum; none of the pat
ients with anechoic fluid or no detected fluid had hemoperitoneum (0%)
. Echogenic fluid had a sensitivity of 100%, specificity of 95%, posit
ive predictive value of 98%, and an accuracy of 98% for detecting hemo
peritoneum. This study demonstrates that echogenic fluid detected by t
ransvaginal ultrasonography accurately correlates with hemoperitoneum
detected at surgery in patients with suspected ectopic pregnancy.