LOCALIZATION OF X-CHROMOSOME SHORT ARM MARKERS RELATIVE TO SYNOVIAL SARCOMA-ASSOCIATED AND RENAL ADENOCARCINOMA-ASSOCIATED TRANSLOCATION BREAKPOINTS

Authors
SINKE RJ DELEEUW B JANSSEN HAP WEGHUIS DO SUIJKERBUIJK RF MELONI AM GILGENKRANTZ S BERGER W ROPERS HH SANDBERG AA VANKESSEL AG
Citation
Rj. Sinke et al., LOCALIZATION OF X-CHROMOSOME SHORT ARM MARKERS RELATIVE TO SYNOVIAL SARCOMA-ASSOCIATED AND RENAL ADENOCARCINOMA-ASSOCIATED TRANSLOCATION BREAKPOINTS, Human genetics, 92(3), 1993, pp. 305-308
Citations number
21
Categorie Soggetti
Genetics & Heredity
Journal title
Human genetics → ACNP
ISSN journal
03406717
Volume
92
Issue
3
Year of publication
1993
Pages
305 - 308
Database
ISI
SICI code
0340-6717(1993)92:3<305:LOXSAM>2.0.ZU;2-F
Abstract
A series of thirteen different DNA markers was mapped relative to papi llary renal cell carcinoma- and synovial sarcoma-associated translocat ion breakpoints in Xp11.2 using a panel of tumor-derived somatic cell hybrids in conjunction with Southern blot analysis. Our results indica te that the two translocation breakpoints differ from each other and t hat the chromosomal break in t(X;1)-positive papillary renal cell carc inoma is located between the markers PFC-TIMP-OATL1-SYP-TFE3 and DXS22 6-DXS146-DXS255-OATL2-DXS14. In addition, our current breakpoint analy sis has resulted in a revision of the regional localization of the pro ximal Xp marker DXS226.