ACTIVE SLEEP IN COLD-EXPOSED INFANT NORWAY RATS AND SYRIAN GOLDEN-HAMSTERS - THE ROLE OF BROWN ADIPOSE-TISSUE THERMOGENESIS

It was previously hypothesized that brown adipose tissue (BAT) thermog enesis helps to maintain high rates of myoclonic twitching during cold exposure in infant rats (M. S. Blumberg & M. A. Stolba, 1996). To tes t this hypothesis, the sensitivity of twitching to various levels of c old exposure was assessed in week-old rats that were untreated or whos e BAT thermogenesis was inhibited using a ganglionic blocker. Because week-old golden hamsters do not exhibit BAT thermogenesis, their sleep behaviors during cold exposure also were examined. Additional investi gations in infant rats were conducted in which supplemental heat was p rovided to the interscapular region using a thermode and in which BAT was activated pharmacologically in ganglionically blocked pups. The re sults support the hypothesis that myoclonic twitching is sensitive to the prevailing air temperature and the activation of BAT thermogenesis .